CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice

Karoline Droebnera, Christina Ehrhardtb, Anne Poetterc, Stephan Ludwigb and Oliver Planza, , ,

a\Friedrich-Loeffler-Institut, Institute of Immunology, Paul-Ehrlich Str. 28, D-72076 Tübingen, Germany

b\Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-Universität, Von Esmarsch-Str. 56, D-48159 Muenster, Germany

cDr. Pandalis Naturprodukte GmbH & Co. KG, Füchtenweg 3, D-49219 Glandorf, Germany


Influenza, a respiratory disease caused by influenza viruses, is still a worldwide threat with a high potential to cause a pandemic. Beside vaccination, only two classes of drugs are available for antiviral treatment against the pathogen. Here we show that CYSTUS052, a plant extract from a special variety of Cistus incanus that is rich in polymeric polyphenols, exhibits antiviral activity against a highly pathogenic avian influenza A virus (H7N7) in cell culture and in a mouse infection model. In vitro and in vivo treatment was performed with an aerosol formulation, because the bioavailability of high molecular weight polyphenols is poor. In MDCK cells, a 90% reduction of plaque numbers on cells pre-incubated with the plant extract was achieved. For in vivo experiments we used a novel monitoring system for influenza A virus-infected mice that allows measurement of body temperature and gross motor-activity of the animals. Mice treated with CYSTUS052 did not develop disease, showed neither differences in their body temperature nor differences in their gross motor-activity and exhibited no histological alterations of the bronchiolus epithelial cells.

Northern Crete

Cistus incanus from northern Crete they is unique that produces the laudanum and is the most possible.

On line Shop from the real labdanum resin and essential oil Cistus Incanus


BCas said...

Oi Dimitris.
Muito interessante ! O estudo indica outras plantas ricas nestes polifenóis ?
certamente cistus deve ser uma entre várias . beijocas
Very Interesting! The study do not indicate other rich plants in polymeric polyphenols? Certainly cistus is one between several.XOXO. Elisabeth

BCas said...

No meu blog tenho um espaço para escrever sobre a gripe H1N1. Colocarei um link da sua página. Beijocas

In mine blog I have a space to write on H1N1 influenza. I will place one link of its page. XOXO. Elisabeth

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